pI: 10.0498 |
Length (AA): 490 |
MW (Da): 57131 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
71 | 490 | 1oyw (A) | 3 | 427 | 18.00 | 0 | 1 | 1 | -0.95 |
72 | 278 | 1vec (A) | 87 | 287 | 26.00 | 0 | 1 | 0.96 | -2.42 |
72 | 438 | 2db3 (A) | 247 | 610 | 29.00 | 0 | 1 | 1.3 | -2.17 |
29 | 486 | 2eyq (A) | 543 | 967 | 16.00 | 0 | 1 | 0.969294 | 0.56 |
58 | 271 | 3ber (A) | 12 | 219 | 41.00 | 0 | 1 | 1.07233 | -1.84 |
71 | 452 | 4c9b (A) | 39 | 411 | 29.00 | 0 | 1 | 1.22789 | -0.89 |
71 | 271 | 1vec (A) | 86 | 280 | 27.00 | 0 | 1 | 0.872804 | -1.63 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 24 hs, Ring, Male Gametocyte. | Otto TD Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early trophozoite, late ring, late trophozoite, Oocyst, Sporozoite, Female Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | early schizont. | PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Ortholog group members (OG5_128272)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G16280 | DEAD-box ATP-dependent RNA helicase 36 |
Babesia bovis | BBOV_III005880 | DEAD/DEAH box helicase family protein |
Brugia malayi | Bm1_16875 | Helicase conserved C-terminal domain containing protein |
Candida albicans | CaO19.13973 | similar to S. cerevisiae DBP8 (YHR169W) ATP-dependent RNA helicase involved in rRNA processing |
Candida albicans | CaO19.6652 | similar to S. cerevisiae DBP8 (YHR169W) ATP-dependent RNA helicase involved in rRNA processing |
Caenorhabditis elegans | CELE_H20J04.4 | Protein H20J04.4, isoform A |
Cryptosporidium hominis | Chro.10035 | ATP-dependent RNA helicase |
Cryptosporidium parvum | cgd1_250 | ATP-dependent RNA helicase, putative |
Dictyostelium discoideum | DDB_G0270396 | DEAD/DEAH box helicase |
Drosophila melanogaster | Dmel_CG12759 | DEAD box protein 45A |
Echinococcus granulosus | EgrG_000805100 | ATP dependent RNA helicase DDX49 |
Entamoeba histolytica | EHI_027760 | DEAD/DEAH box helicase, putative |
Echinococcus multilocularis | EmuJ_000035000 | ATP dependent RNA helicase DDX49 |
Echinococcus multilocularis | EmuJ_000805100 | ATP dependent RNA helicase DDX49 |
Giardia lamblia | GL50803_95898 | ATP-dependent RNA helicase |
Homo sapiens | ENSG00000105671 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 |
Leishmania braziliensis | LbrM.05.0360 | ATP-dependent RNA helicase, putative |
Leishmania donovani | LdBPK_050360.1 | ATP-dependent RNA helicase, putative |
Leishmania infantum | LinJ.05.0360 | ATP-dependent RNA helicase, putative |
Leishmania major | LmjF.05.0360 | ATP-dependent RNA helicase, putative |
Leishmania mexicana | LmxM.05.0360 | ATP-dependent RNA helicase, putative |
Loa Loa (eye worm) | LOAG_01335 | Ddx49-A-prov protein |
Mus musculus | ENSMUSG00000057788 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 |
Neospora caninum | NCLIV_001850 | ATP-dependent RNA helicase, putative |
Oryza sativa | 4344011 | Os07g0633500 |
Plasmodium berghei | PBANKA_1347500 | ATP-dependent RNA helicase DBP8, putative |
Plasmodium falciparum | PF3D7_1332700 | ATP-dependent RNA helicase DBP8, putative |
Plasmodium knowlesi | PKNH_1267900 | ATP-dependent RNA helicase DBP8, putative |
Plasmodium vivax | PVX_082565 | DEAD/DEAH box helicase domain containing protein |
Plasmodium yoelii | PY05724 | putative ATP-dependent RNA helicase |
Saccharomyces cerevisiae | YHR169W | ATP-dependent RNA helicase DBP8 |
Schistosoma japonicum | Sjp_0024960 | ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative |
Schistosoma mansoni | Smp_123410.1 | DEAD box ATP-dependent RNA helicase |
Schistosoma mansoni | Smp_123410.2 | DEAD box ATP-dependent RNA helicase |
Schmidtea mediterranea | mk4.011023.00 | Probable ATP-dependent RNA helicase DDX49 |
Schmidtea mediterranea | mk4.000139.10 | Kinesin heavy chain |
Schmidtea mediterranea | mk4.021997.01 | Probable ATP-dependent RNA helicase DDX49 |
Trypanosoma brucei gambiense | Tbg972.10.12660 | ATP-dependent DEAD/H RNA helicase, putative |
Trypanosoma brucei | Tb927.10.10380 | ATP-dependent DEAD/H RNA helicase, putative |
Trypanosoma congolense | TcIL3000_10_8860 | ATP-dependent DEAD/H RNA helicase, putative |
Trypanosoma cruzi | TcCLB.503555.40 | ATP-dependent RNA helicase, putative |
Trypanosoma cruzi | TcCLB.484299.4 | ATP-dependent DEAD/H RNA helicase, putative |
Toxoplasma gondii | TGME49_295010 | DEAD/DEAH box helicase domain-containing protein |
Theileria parva | TP02_0332 | ATP-dependent RNA helicase, putative |
Trichomonas vaginalis | TVAG_437230 | DEAD box ATP-dependent RNA helicase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.10380 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.10380 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.10380 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.10380 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_H20J04.4 | Caenorhabditis elegans | slow growth | wormbase |
YHR169W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_295010 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
2 literature references were collected for this gene.